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Interferon alpha-inducible protein 6 regulates NRASQ61K-induced melanomagenesis and growth
Mutations in the NRAS oncogene are present in up to 20% of melanoma. Here, we show that interferon alpha-inducible protein 6 (IFI6) is necessary for NRASQ61K-induced transformation and melanoma growth. IFI6 was transcriptionally upregulated by NRASQ61K, and knockdown of IFI6 resulted in DNA replicat...
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| Publicado no: | eLife |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
eLife Sciences Publications, Ltd
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5031487/ https://ncbi.nlm.nih.gov/pubmed/27608486 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.16432 |
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