Interferon alpha-inducible protein 6 regulates NRASQ61K-induced melanomagenesis and growth

Mutations in the NRAS oncogene are present in up to 20% of melanoma. Here, we show that interferon alpha-inducible protein 6 (IFI6) is necessary for NRASQ61K-induced transformation and melanoma growth. IFI6 was transcriptionally upregulated by NRASQ61K, and knockdown of IFI6 resulted in DNA replicat...

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Dades bibliogràfiques
Publicat a:eLife
Autors principals: Gupta, Romi, Forloni, Matteo, Bisserier, Malik, Dogra, Shaillay Kumar, Yang, Qiaohong, Wajapeyee, Narendra
Format: Artigo
Idioma:Inglês
Publicat: eLife Sciences Publications, Ltd 2016
Matèries:
Cancer Biology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5031487/
https://ncbi.nlm.nih.gov/pubmed/27608486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.16432
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