Digestion of Chromatin in Apoptotic Cell Microparticles Prevents Autoimmunity

Antibodies to DNA and chromatin drive autoimmunity in systemic lupus erythematosus (SLE). Null mutations and hypomorphic variants of the secreted deoxyribonuclease DNASE1L3 are linked to familial and sporadic SLE, respectively. We report that DNASE1L3-deficient mice rapidly develop autoantibodies to...

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Publicado no:Cell
Main Authors: Sisirak, Vanja, Sally, Benjamin, D’Agati, Vivette, Martinez-Ortiz, Wilnelly, Özçakar, Z. Birsin, David, Joseph, Rashidfarrokhi, Ali, Yeste, Ada, Panea, Casandra, Chida, Asiya Seema, Bogunovic, Milena, Ivanov, Ivaylo I., Quintana, Francisco J., Sanz, Inaki, Elkon, Keith B., Tekin, Mustafa, Yalçınkaya, Fatoş, Cardozo, Timothy J., Clancy, Robert M., Buyon, Jill P., Reizis, Boris
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5030815/
https://ncbi.nlm.nih.gov/pubmed/27293190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2016.05.034
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