Digestion of Chromatin in Apoptotic Cell Microparticles Prevents Autoimmunity

Antibodies to DNA and chromatin drive autoimmunity in systemic lupus erythematosus (SLE). Null mutations and hypomorphic variants of the secreted deoxyribonuclease DNASE1L3 are linked to familial and sporadic SLE, respectively. We report that DNASE1L3-deficient mice rapidly develop autoantibodies to...

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Vydáno v:Cell
Hlavní autoři: Sisirak, Vanja, Sally, Benjamin, D’Agati, Vivette, Martinez-Ortiz, Wilnelly, Özçakar, Z. Birsin, David, Joseph, Rashidfarrokhi, Ali, Yeste, Ada, Panea, Casandra, Chida, Asiya Seema, Bogunovic, Milena, Ivanov, Ivaylo I., Quintana, Francisco J., Sanz, Inaki, Elkon, Keith B., Tekin, Mustafa, Yalçınkaya, Fatoş, Cardozo, Timothy J., Clancy, Robert M., Buyon, Jill P., Reizis, Boris
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5030815/
https://ncbi.nlm.nih.gov/pubmed/27293190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2016.05.034
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