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Novel de novo mutations in KIF1A as a cause of hereditary spastic paraplegia with progressive central nervous system involvement

Hereditary spastic paraplegias (HSPs) are a clinically and genetically heterogeneous group of disorders characterized by lower extremity spasticity and weakness. Recently, the first de novo mutations in KIF1A were identified in patients with an early onset severe form of complicated HSP. We report t...

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Vydáno v:J Child Neurol
Hlavní autoři: Hotchkiss, Leslie, Donkervoort, Sandra, Leach, Meganne, Mohassel, Payam, Bharucha-Goebel, Diana X., Bradley, Nathaniel, Nguyen, David, Hu, Ying, Gurgel-Giannetti, Juliana, Bönnemann, Carsten G.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5030766/
https://ncbi.nlm.nih.gov/pubmed/27034427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/0883073816639718
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