Development of a 3D Tissue Culture–Based High-Content Screening Platform That Uses Phenotypic Profiling to Discriminate Selective Inhibitors of Receptor Tyrosine Kinases

3D tissue cultures provide a more physiologically relevant context for the screening of compounds, compared with 2D cell cultures. Cells cultured in 3D hydrogels also show complex phenotypes, increasing the scope for phenotypic profiling. Here we describe a high-content screening platform that uses...

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Detalles Bibliográficos
Publicado en:SLAS Discov
Main Authors: Booij, Tijmen H., Klop, Maarten J. D., Yan, Kuan, Szántai-Kis, Csaba, Szokol, Balint, Orfi, Laszlo, van de Water, Bob, Keri, Gyorgy, Price, Leo S.
Formato: Artigo
Idioma:Inglês
Publicado: SAGE Publications 2016
Assuntos:
Special Collection
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5030728/
https://ncbi.nlm.nih.gov/pubmed/27412535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1087057116657269
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