Development of a 3D Tissue Culture–Based High-Content Screening Platform That Uses Phenotypic Profiling to Discriminate Selective Inhibitors of Receptor Tyrosine Kinases

3D tissue cultures provide a more physiologically relevant context for the screening of compounds, compared with 2D cell cultures. Cells cultured in 3D hydrogels also show complex phenotypes, increasing the scope for phenotypic profiling. Here we describe a high-content screening platform that uses...

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Publicat a:SLAS Discov
Autors principals: Booij, Tijmen H., Klop, Maarten J. D., Yan, Kuan, Szántai-Kis, Csaba, Szokol, Balint, Orfi, Laszlo, van de Water, Bob, Keri, Gyorgy, Price, Leo S.
Format: Artigo
Idioma:Inglês
Publicat: SAGE Publications 2016
Matèries:
Special Collection
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5030728/
https://ncbi.nlm.nih.gov/pubmed/27412535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1087057116657269
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