Development of a 3D Tissue Culture–Based High-Content Screening Platform That Uses Phenotypic Profiling to Discriminate Selective Inhibitors of Receptor Tyrosine Kinases

3D tissue cultures provide a more physiologically relevant context for the screening of compounds, compared with 2D cell cultures. Cells cultured in 3D hydrogels also show complex phenotypes, increasing the scope for phenotypic profiling. Here we describe a high-content screening platform that uses...

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Bibliografiske detaljer
Udgivet i:SLAS Discov
Main Authors: Booij, Tijmen H., Klop, Maarten J. D., Yan, Kuan, Szántai-Kis, Csaba, Szokol, Balint, Orfi, Laszlo, van de Water, Bob, Keri, Gyorgy, Price, Leo S.
Format: Artigo
Sprog:Inglês
Udgivet: SAGE Publications 2016
Fag:
Special Collection
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5030728/
https://ncbi.nlm.nih.gov/pubmed/27412535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1087057116657269
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