Guanylate-Binding Protein-1 protects ovarian cancer cell lines but not breast cancer cell lines from killing by paclitaxel

Forced expression of the cytokine-induced large GTPase, human Guanylate-Binding Protein-1 (hGBP-1), in ovarian cancer cell lines increases resistance to paclitaxel. Elevated hGBP-1 RNA in ovarian tumors correlates with shorter recurrence-free survival. In contract, hGBP-1 is part of a gene signature...

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Publicado no:Biochem Biophys Res Commun
Main Authors: Tipton, Aaron R., Nyabuto, Geoffrey O., Trendel, Jill A., Mazur, Travis M., Wilson, John P., Wadi, Suzan, Justinger, Jacob S., Moore, Garret L., Nguyen, Peter T., Vestal, Deborah J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5030188/
https://ncbi.nlm.nih.gov/pubmed/27590579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2016.08.169
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