Hypoxia-regulated gene expression explains differences between melanoma cell line-derived xenografts and patient-derived xenografts

Cell line-derived xenografts (CDXs) are an integral part of drug efficacy testing during development of new pharmaceuticals against cancer but their accuracy in predicting clinical responses in patients have been debated. Patient-derived xenografts (PDXs) are thought to be more useful for predictive...

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Bibliographic Details
Published in:Oncotarget
Main Authors: Bhadury, Joydeep, Einarsdottir, Berglind O., Podraza, Agnieszka, Bagge, Roger Olofsson, Stierner, Ulrika, Ny, Lars, López, Marcela Dávila, Nilsson, Jonas A.
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2016
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5029664/
https://ncbi.nlm.nih.gov/pubmed/27009863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.8181
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