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Hypoxia-regulated gene expression explains differences between melanoma cell line-derived xenografts and patient-derived xenografts

Cell line-derived xenografts (CDXs) are an integral part of drug efficacy testing during development of new pharmaceuticals against cancer but their accuracy in predicting clinical responses in patients have been debated. Patient-derived xenografts (PDXs) are thought to be more useful for predictive...

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Bibliographische Detailangaben
Veröffentlicht in:Oncotarget
Hauptverfasser: Bhadury, Joydeep, Einarsdottir, Berglind O., Podraza, Agnieszka, Bagge, Roger Olofsson, Stierner, Ulrika, Ny, Lars, López, Marcela Dávila, Nilsson, Jonas A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2016
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5029664/
https://ncbi.nlm.nih.gov/pubmed/27009863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.8181
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