The pathological role of advanced glycation end products-downregulated heat shock protein 60 in islet β-cell hypertrophy and dysfunction

Heat shock protein 60 (HSP60) is a mitochondrial chaperone. Advanced glycation end products (AGEs) have been shown to interfere with the β-cell function. We hypothesized that AGEs induced β-cell hypertrophy and dysfunction through a HSP60 dysregulation pathway during the stage of islet/β-cell hypert...

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Veröffentlicht in:Oncotarget
Hauptverfasser: Guan, Siao-Syun, Sheu, Meei-Ling, Yang, Rong-Sen, Chan, Ding-Cheng, Wu, Cheng-Tien, Yang, Ting-Hua, Chiang, Chih-Kang, Liu, Shing-Hwa
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2016
Schlagworte:
Research Paper: Pathology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5029611/
https://ncbi.nlm.nih.gov/pubmed/27056903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.8604
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