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Modulation of Phenotype and Function of Human CD4(+)CD25(+) T Regulatory Lymphocytes Mediated by cAMP-Elevating Agents

We have shown that cholera toxin (CT) and other cyclic AMP (cAMP)-elevating agents induce upregulation of the inhibitory molecule CTLA-4 in human resting CD4(+) T lymphocytes, which following the treatment acquired suppressive functions. In this study, we evaluated the effect of cAMP-elevating agent...

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Библиографические подробности
Опубликовано в: :Front Immunol
Главные авторы: Riccomi, Antonella, Gesa, Valentina, Sacchi, Alessandra, De Magistris, Maria Teresa, Vendetti, Silvia
Формат: Artigo
Язык:Inglês
Опубликовано: Frontiers Media S.A. 2016
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5028705/
https://ncbi.nlm.nih.gov/pubmed/27703455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2016.00358
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