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Prediction of Drug Penetration in Tuberculosis Lesions
The penetration of antibiotics in necrotic tuberculosis lesions is heterogeneous and drug-specific, but the factors underlying such differential partitioning are unknown. We hypothesized that drug binding to macromolecules in necrotic foci (or caseum) prevents passive drug diffusion through avascula...
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| Publicado en: | ACS Infect Dis |
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| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2016
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5028112/ https://ncbi.nlm.nih.gov/pubmed/27626295 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsinfecdis.6b00051 |
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