Costimulatory Effects of an Immunodominant Parasite Antigen Paradoxically Prevent Induction of Optimal CD8 T Cell Protective Immunity

Trypanosoma cruzi infection is controlled but not eliminated by host immunity. The T. cruzi trans-sialidase (TS) gene superfamily encodes immunodominant protective antigens, but expression of altered peptide ligands by different TS genes has been hypothesized to promote immunoevasion. We molecularly...

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Publicat a:PLoS Pathog
Autors principals: Eickhoff, Christopher S., Zhang, Xiuli, Vasconcelos, Jose R., Motz, R. Geoffrey, Sullivan, Nicole L., O’Shea, Kelly, Pozzi, Nicola, Gohara, David W., Blase, Jennifer R., Di Cera, Enrico, Hoft, Daniel F.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2016
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5028030/
https://ncbi.nlm.nih.gov/pubmed/27642757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1005896
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