MUTATED KCNJ5 ACTIVATES THE ACUTE AND CHRONIC REGULATORY STEPS IN ALDOSTERONE PRODUCTION

Somatic and germline mutations in the inward rectifying K(+) channel (KCNJ5) are a common cause of primary aldosteronism (PA) in aldosterone producing adenoma and familial hyperaldosteronism type III, respectively. Dysregulation of adrenal cell calcium signaling represents one mechanism for mutated...

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Detalhes bibliográficos
Publicado no:J Mol Endocrinol
Main Authors: Hattangady, Namita G., Karashima, Shigehiro, Yuan, Lucy, Ponce-Balbuena, Daniela, Jalife, José, Gomez-Sanchez, Celso E., Auchus, Richard J., Rainey, William E., Else, Tobias
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5027885/
https://ncbi.nlm.nih.gov/pubmed/27099398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1530/JME-15-0324
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