Thiazolidinedione Drugs Promote Onset, Alter Characteristics, and Increase Mortality of Ischemic Ventricular Fibrillation in Pigs

PURPOSE: Despite favorable metabolic and vascular effects, thiazolidinedione (TZD) drugs have not convincingly reduced cardiovascular mortality in clinical trials, raising the possibility of countervailing, off-target effects. We previously showed that TZDs block cardiac ATP-sensitive potassium (K(A...

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Veröffentlicht in:Cardiovasc Drugs Ther
Hauptverfasser: Sarraf, Mohammad, Lu, Li, Ye, Shuyu, Reiter, Michael J., Greyson, Clifford R., Schwartz, Gregory G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5027884/
https://ncbi.nlm.nih.gov/pubmed/22450779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10557-012-6384-2
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