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Phosphorylation of Ku70 subunit by cell cycle kinases modulates the replication related function of Ku heterodimer
The Ku protein, a heterodimer of Ku70 and Ku80, binds to chromosomal replication origins maximally at G1-phase and plays an essential role in assembly of origin recognition complex. However, the mechanism regulating such a critical periodic activity of Ku remained unknown. Here, we establish human K...
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| Pubblicato in: | Nucleic Acids Res |
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| Autori principali: | , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Oxford University Press
2016
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5027504/ https://ncbi.nlm.nih.gov/pubmed/27402161 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw622 |
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