SHAPE reveals transcript-wide interactions, complex structural domains, and protein interactions across the Xist lncRNA in living cells

The 18-kb Xist long noncoding RNA (lncRNA) is essential for X-chromosome inactivation during female eutherian mammalian development. Global structural architecture, cell-induced conformational changes, and protein–RNA interactions within Xist are poorly understood. We used selective 2′-hydroxyl acyl...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Smola, Matthew J., Christy, Thomas W., Inoue, Kaoru, Nicholson, Cindo O., Friedersdorf, Matthew, Keene, Jack D., Lee, David M., Calabrese, J. Mauro, Weeks, Kevin M.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2016
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5027438/
https://ncbi.nlm.nih.gov/pubmed/27578869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1600008113
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker