SHAPE reveals transcript-wide interactions, complex structural domains, and protein interactions across the Xist lncRNA in living cells

The 18-kb Xist long noncoding RNA (lncRNA) is essential for X-chromosome inactivation during female eutherian mammalian development. Global structural architecture, cell-induced conformational changes, and protein–RNA interactions within Xist are poorly understood. We used selective 2′-hydroxyl acyl...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Smola, Matthew J., Christy, Thomas W., Inoue, Kaoru, Nicholson, Cindo O., Friedersdorf, Matthew, Keene, Jack D., Lee, David M., Calabrese, J. Mauro, Weeks, Kevin M.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2016
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5027438/
https://ncbi.nlm.nih.gov/pubmed/27578869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1600008113
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