Hijacking an RNA-editing enzyme to identify cell-specific targets of RNA-binding proteins

RNA transcripts are bound and regulated by RNA-binding proteins (RBPs). Current methods for identifying in vivo targets of a RBP are imperfect and not amenable to examining small numbers of cells. To address these issues, we developed TRIBE (Targets of RNA-binding proteins Identified By Editing), a...

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Vydáno v:Cell
Hlavní autoři: McMahon, Aoife C, Rahman, Reazur, Jin, Hua, Shen, James L, Fieldsend, Allegra, Luo, Weifei, Rosbash, Michael
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5027142/
https://ncbi.nlm.nih.gov/pubmed/27040499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2016.03.007
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