Cancer associated fibroblasts in pancreatic cancer are reprogrammed by tumor-induced alterations in genomic DNA methylation

Stromal fibrosis is a prominent histological characteristic of pancreatic ductal adenocarcinoma (PDAC), but how stromal fibroblasts are regulated in the tumor microenvironment (TME) to support tumor growth is largely unknown. Here we show that PDAC cells can induce DNA methylation in cancer associat...

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Bibliografske podrobnosti
izdano v:Cancer Res
Main Authors: Xiao, Qian, Zhou, Donger, Rucki, Agnieszka A., Williams, Jamila, Zhou, Jiaojiao, Mo, Guanglan, Murphy, Adrian, Fujiwara, Kenji, Kleponis, Jennifer, Salman, Bulent, Wolfgang, Christopher L., Anders, Robert A., Zheng, Shu, Jaffee, Elizabeth M., Zheng, Lei
Format: Artigo
Jezik:Inglês
Izdano: 2016
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5026619/
https://ncbi.nlm.nih.gov/pubmed/27496707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-15-3264
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