Cancer associated fibroblasts in pancreatic cancer are reprogrammed by tumor-induced alterations in genomic DNA methylation

Stromal fibrosis is a prominent histological characteristic of pancreatic ductal adenocarcinoma (PDAC), but how stromal fibroblasts are regulated in the tumor microenvironment (TME) to support tumor growth is largely unknown. Here we show that PDAC cells can induce DNA methylation in cancer associat...

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Publicado en:Cancer Res
Main Authors: Xiao, Qian, Zhou, Donger, Rucki, Agnieszka A., Williams, Jamila, Zhou, Jiaojiao, Mo, Guanglan, Murphy, Adrian, Fujiwara, Kenji, Kleponis, Jennifer, Salman, Bulent, Wolfgang, Christopher L., Anders, Robert A., Zheng, Shu, Jaffee, Elizabeth M., Zheng, Lei
Formato: Artigo
Idioma:Inglês
Publicado: 2016
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5026619/
https://ncbi.nlm.nih.gov/pubmed/27496707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-15-3264
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