Tissue stiffness and hypoxia modulate the integrin-linked kinase ILK to control breast cancer stem-like cells

Breast tumors are stiffer and hypoxic compared to nonmalignant breast tissue. Here we report that stiff and hypoxic microenvironments promote the development of breast cancer stem-like cells (CSC) through modulation of the integrin-linked kinase ILK. Depleting ILK blocked stiffness and hypoxia-depen...

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Udgivet i:Cancer Res
Main Authors: Pang, Mei-Fong, Siedlik, Michael J., Han, Siyang, Stallings-Mann, Melody, Radisky, Derek C., Nelson, Celeste M.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5026611/
https://ncbi.nlm.nih.gov/pubmed/27503933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-16-0579
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