A pyruvate decarboxylase-mediated therapeutic strategy for mimicking yeast metabolism in cancer cells

Cancer cells have high rates of glycolysis and lactic acid fermentation in order to fuel accelerated rates of cell division (Warburg effect). Here, we present a strategy for merging cancer and yeast metabolism to remove pyruvate, a key intermediate of cancer cell metabolism, and produce the toxic co...

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Bibliographic Details
Published in:Pharmacol Res
Main Authors: Scott, Bronwyn, Shen, Jianliang, Nizzero, Sara, Boom, Kathryn, Persano, Stefano, Mi, Yu, Liu, Xuewu, Zhao, Yuliang, Blanco, Elvin, Shen, Haifa, Ferrari, Mauro, Wolfram, Joy
Format: Artigo
Language:Inglês
Published: 2016
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5026593/
https://ncbi.nlm.nih.gov/pubmed/27394167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.phrs.2016.07.005
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