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A pyruvate decarboxylase-mediated therapeutic strategy for mimicking yeast metabolism in cancer cells
Cancer cells have high rates of glycolysis and lactic acid fermentation in order to fuel accelerated rates of cell division (Warburg effect). Here, we present a strategy for merging cancer and yeast metabolism to remove pyruvate, a key intermediate of cancer cell metabolism, and produce the toxic co...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | Pharmacol Res |
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| Κύριοι συγγραφείς: | , , , , , , , , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
2016
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5026593/ https://ncbi.nlm.nih.gov/pubmed/27394167 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.phrs.2016.07.005 |
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