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A pyruvate decarboxylase-mediated therapeutic strategy for mimicking yeast metabolism in cancer cells
Cancer cells have high rates of glycolysis and lactic acid fermentation in order to fuel accelerated rates of cell division (Warburg effect). Here, we present a strategy for merging cancer and yeast metabolism to remove pyruvate, a key intermediate of cancer cell metabolism, and produce the toxic co...
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| Publicado no: | Pharmacol Res |
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| Main Authors: | , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5026593/ https://ncbi.nlm.nih.gov/pubmed/27394167 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.phrs.2016.07.005 |
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