A pyruvate decarboxylase-mediated therapeutic strategy for mimicking yeast metabolism in cancer cells

Cancer cells have high rates of glycolysis and lactic acid fermentation in order to fuel accelerated rates of cell division (Warburg effect). Here, we present a strategy for merging cancer and yeast metabolism to remove pyruvate, a key intermediate of cancer cell metabolism, and produce the toxic co...

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Veröffentlicht in:Pharmacol Res
Hauptverfasser: Scott, Bronwyn, Shen, Jianliang, Nizzero, Sara, Boom, Kathryn, Persano, Stefano, Mi, Yu, Liu, Xuewu, Zhao, Yuliang, Blanco, Elvin, Shen, Haifa, Ferrari, Mauro, Wolfram, Joy
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5026593/
https://ncbi.nlm.nih.gov/pubmed/27394167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.phrs.2016.07.005
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