Mitochondrial respiration controls lysosomal function during inflammatory T cell responses

The endolysosomal system is critical for the maintenance of cellular homeostasis. However, how endolysosomal compartment is regulated by mitochondrial function is largely unknown. We have generated a mouse model with defective mitochondrial function in CD4(+) T lymphocytes by genetic deletion of the...

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Detalhes bibliográficos
Publicado no:Cell Metab
Main Authors: Baixauli, Francesc, Acín-Pérez, Rebeca, Villarroya-Beltrí, Carolina, Mazzeo, Carla, Nuñez-Andrade, Norman, Gabandé-Rodriguez, Enrique, Dolores Ledesma, Maria, Blázquez, Alberto, Martin, Miguel Angel, Falcón-Pérez, Juan Manuel, Redondo, Juan Miguel, Enríquez, Jose Antonio, Mittelbrunn, Maria
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5026297/
https://ncbi.nlm.nih.gov/pubmed/26299452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2015.07.020
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