IL-15 activates mTOR and primes stress-activated gene expression leading to prolonged antitumor capacity of NK cells

Treatment of hematological malignancies by adoptive transfer of activated natural killer (NK) cells is limited by poor postinfusion persistence. We compared the ability of interleukin-2 (IL-2) and IL-15 to sustain human NK-cell functions following cytokine withdrawal to model postinfusion performanc...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Mao, Yumeng, van Hoef, Vincent, Zhang, Xiaonan, Wennerberg, Erik, Lorent, Julie, Witt, Kristina, Masvidal, Laia, Liang, Shuo, Murray, Shannon, Larsson, Ola, Kiessling, Rolf, Lundqvist, Andreas
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2016
Assuntos:
Immunobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5025899/
https://ncbi.nlm.nih.gov/pubmed/27465917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2016-02-698027
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