IL-15 activates mTOR and primes stress-activated gene expression leading to prolonged antitumor capacity of NK cells

Treatment of hematological malignancies by adoptive transfer of activated natural killer (NK) cells is limited by poor postinfusion persistence. We compared the ability of interleukin-2 (IL-2) and IL-15 to sustain human NK-cell functions following cytokine withdrawal to model postinfusion performanc...

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Publicado en:Blood
Autores principales: Mao, Yumeng, van Hoef, Vincent, Zhang, Xiaonan, Wennerberg, Erik, Lorent, Julie, Witt, Kristina, Masvidal, Laia, Liang, Shuo, Murray, Shannon, Larsson, Ola, Kiessling, Rolf, Lundqvist, Andreas
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Hematology 2016
Materias:
Immunobiology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5025899/
https://ncbi.nlm.nih.gov/pubmed/27465917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2016-02-698027
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