Limited clonal relatedness between gut IgA plasma cells and memory B cells after oral immunization

Understanding how memory B cells are induced and relate to long-lived plasma cells is important for vaccine development. Immunity to oral vaccines has been considered short-lived because of a poor ability to develop IgA B-cell memory. Here we demonstrate that long-lived mucosal IgA memory is readily...

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Publicado no:Nat Commun
Main Authors: Bemark, Mats, Hazanov, Helena, Strömberg, Anneli, Komban, Rathan, Holmqvist, Joel, Köster, Sofia, Mattsson, Johan, Sikora, Per, Mehr, Ramit, Lycke, Nils Y.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5025876/
https://ncbi.nlm.nih.gov/pubmed/27596266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms12698
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