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Chronic Kappa opioid receptor activation modulates NR2B: Implication in treatment resistant depression

Psychotomimetic and prodepressive effect by kappa opioid receptor (KOR) activation in rodents and human is widely known. Significantly, recent clinical investigations demonstrated the salutary effects of KOR antagonists in patients with treatment resistant depression, indicating essential role of KO...

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Enregistré dans:
Détails bibliographiques
Publié dans:Sci Rep
Auteurs principaux: Dogra, Shalini, Kumar, Ajeet, Umrao, Deepmala, Sahasrabuddhe, Amogh A., Yadav, Prem N.
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2016
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5025743/
https://ncbi.nlm.nih.gov/pubmed/27634008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep33401
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