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Investigation of rare and low-frequency variants using high-throughput sequencing with pooled DNA samples
High-throughput sequencing using pooled DNA samples can facilitate genome-wide studies on rare and low-frequency variants in a large population. Some major questions concerning the pooling sequencing strategy are whether rare and low-frequency variants can be detected reliably, and whether estimated...
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| Опубликовано в: : | Sci Rep |
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| Главные авторы: | , , , , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Nature Publishing Group
2016
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5025741/ https://ncbi.nlm.nih.gov/pubmed/27633116 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep33256 |
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