Exome sequencing in pooled DNA samples to identify maternal pre-eclampsia risk variants

Pre-eclampsia is a common pregnancy disorder that is a major cause for maternal and perinatal mortality and morbidity. Variants predisposing to pre-eclampsia might be under negative evolutionary selection that is likely to keep their population frequencies low. We exome sequenced samples from a hund...

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Published in:Sci Rep
Main Authors: Kaartokallio, Tea, Wang, Jingwen, Heinonen, Seppo, Kajantie, Eero, Kivinen, Katja, Pouta, Anneli, Gerdhem, Paul, Jiao, Hong, Kere, Juha, Laivuori, Hannele
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4935848/
https://ncbi.nlm.nih.gov/pubmed/27384325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep29085
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