A Multidimensional Diversity‐Oriented Synthesis Strategy for Structurally Diverse and Complex Macrocycles

Synthetic macrocycles are an attractive area in drug discovery. However, their use has been hindered by a lack of versatile platforms for the generation of structurally (and thus shape) diverse macrocycle libraries. Herein, we describe a new concept in library synthesis, termed multidimensional dive...

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Detalhes bibliográficos
Publicado no:Angew Chem Int Ed Engl
Main Authors: Nie, Feilin, Kunciw, Dominique L., Wilcke, David, Stokes, Jamie E., Galloway, Warren R. J. D., Bartlett, Sean, Sore, Hannah F., Spring, David R.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
Assuntos:
Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5025730/
https://ncbi.nlm.nih.gov/pubmed/27484830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201605460
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