Regulation of Ubiquitin-like with Plant Homeodomain and RING Finger Domain 1 (UHRF1) Protein Stability by Heat Shock Protein 90 Chaperone Machinery

As a protein critical for DNA maintenance methylation and cell proliferation, UHRF1 is frequently highly expressed in various human cancers and is considered as a drug target for cancer therapy. In a high throughput screening for small molecules that induce UHRF1 protein degradation, we have identif...

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Vydáno v:J Biol Chem
Hlavní autoři: Ding, Guangjin, Chen, Peilin, Zhang, Hui, Huang, Xiaojie, Zang, Yi, Li, Jiwen, Li, Jia, Wong, Jiemin
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2016
Témata:
DNA and Chromosomes
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5025696/
https://ncbi.nlm.nih.gov/pubmed/27489107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.727214
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