Starving cancer from the outside and inside: separate and combined effects of calorie restriction and autophagy inhibition on Ras-driven tumors

BACKGROUND: Calorie restriction (CR) prevents obesity and exerts anticancer effects in many preclinical models. CR is also increasingly being used in cancer patients as a sensitizing strategy prior to chemotherapy regimens. While the beneficial effects of CR are widely accepted, the mechanisms throu...

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Detalhes bibliográficos
Publicado no:Cancer Metab
Main Authors: Lashinger, Laura M., O’Flanagan, Ciara H., Dunlap, Sarah M., Rasmussen, Audrey J., Sweeney, Shannon, Guo, Jessie Yangxiang, Lodi, Alessia, Tiziani, Stefano, White, Eileen, Hursting, Stephen D.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5025535/
https://ncbi.nlm.nih.gov/pubmed/27651895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40170-016-0158-4
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