Differential Cytotoxic Effects of 7-Dehydrocholesterol-derived Oxysterols on Cultured Retina-derived Cells: Dependence on Sterol Structure, Cell Type, and Density

Tissue accumulation of 7-dehydrocholesterol (7DHC) is a hallmark of Smith-Lemli-Opitz Syndrome (SLOS), a human inborn error of the cholesterol (CHOL) synthesis pathway. Retinal 7DHC-derived oxysterol formation occurs in the AY9944-induced rat model of SLOS, which exhibits a retinal degeneration char...

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Udgivet i:Exp Eye Res
Main Authors: Pfeffer, Bruce A., Xu, Libin, Porter, Ned A., Rao, Sriganesh Ramachandra, Fliesler, Steven J.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5024725/
https://ncbi.nlm.nih.gov/pubmed/26854824
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exer.2016.01.016
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