p53 down-regulates SARS coronavirus replication and is targeted by the SARS-unique domain and PL(pro) via E3 ubiquitin ligase RCHY1

Highly pathogenic severe acute respiratory syndrome coronavirus (SARS-CoV) has developed strategies to inhibit host immune recognition. We identify cellular E3 ubiquitin ligase ring-finger and CHY zinc-finger domain-containing 1 (RCHY1) as an interacting partner of the viral SARS-unique domain (SUD)...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Ma-Lauer, Yue, Carbajo-Lozoya, Javier, Hein, Marco Y., Müller, Marcel A., Deng, Wen, Lei, Jian, Meyer, Benjamin, Kusov, Yuri, von Brunn, Brigitte, Bairad, Dev Raj, Hünten, Sabine, Drosten, Christian, Hermeking, Heiko, Leonhardt, Heinrich, Mann, Matthias, Hilgenfeld, Rolf, von Brunn, Albrecht
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2016
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PNAS Plus
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5024628/
https://ncbi.nlm.nih.gov/pubmed/27519799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1603435113
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