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Delivery of the Porcupine Inhibitor WNT974 in Mice
We describe here a technique for delivering the porcupine inhibitor WNT974 (formerly LGK974) in mice. The protocol entails once-a-day oral delivery of WNT974 for up to 3 months at a concentration sufficient to achieve systemic Wnt pathway inhibition with limited toxicity as measured by weight change...
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| Publicado no: | Methods Mol Biol |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5024565/ https://ncbi.nlm.nih.gov/pubmed/27590157 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/978-1-4939-6393-5_12 |
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