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HSV-2 glycoprotein gD targets the CC domain of tetherin and promotes tetherin degradation via lysosomal pathway

BACKGROUND: HSV-2 is the major cause of genital herpes. We previously demonstrated that the host viral restriction factor tetherin restricts HSV-2 release and is antagonized by several HSV-2 glycoproteins. However, the mechanisms underlying HSV-2 glycoproteins mediated counteraction of tetherin rema...

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Bibliografiske detaljer
Udgivet i:Virol J
Main Authors: Liu, Yalan, Li, Mei, Zhang, Di, Zhang, Mudan, Hu, Qinxue
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5024446/
https://ncbi.nlm.nih.gov/pubmed/27630089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12985-016-0610-7
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