SELMAP - SELEX affinity landscape MAPping of transcription factor binding sites using integrated microfluidics

Transcription factors (TFs) alter gene expression in response to changes in the environment through sequence-specific interactions with the DNA. These interactions are best portrayed as a landscape of TF binding affinities. Current methods to study sequence-specific binding preferences suffer from l...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Chen, Dana, Orenstein, Yaron, Golodnitsky, Rada, Pellach, Michal, Avrahami, Dorit, Wachtel, Chaim, Ovadia-Shochat, Avital, Shir-Shapira, Hila, Kedmi, Adi, Juven-Gershon, Tamar, Shamir, Ron, Gerber, Doron
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5024299/
https://ncbi.nlm.nih.gov/pubmed/27628341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep33351
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