Preclinical Justification of pbi-shRNA EWS/FLI1 Lipoplex (LPX) Treatment for Ewing's Sarcoma

The EWS/FLI1 fusion gene is well characterized as a driver of Ewing's sarcoma. Bi-shRNA EWS/FLI1 is a functional plasmid DNA construct that transcribes both siRNA and miRNA-like effectors each of which targets the identical type 1 translocation junction region of the EWS/FLI1 transcribed mRNA s...

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Detalhes bibliográficos
Publicado no:Mol Ther
Main Authors: Rao, Donald D., Jay, Christopher, Wang, Zhaohui, Luo, Xiuquan, Kumar, Padmasini, Eysenbach, Hilary, Ghisoli, Maurizio, Senzer, Neil, Nemunaitis, John
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5023384/
https://ncbi.nlm.nih.gov/pubmed/27166877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2016.93
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