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Preclinical Justification of pbi-shRNA EWS/FLI1 Lipoplex (LPX) Treatment for Ewing's Sarcoma
The EWS/FLI1 fusion gene is well characterized as a driver of Ewing's sarcoma. Bi-shRNA EWS/FLI1 is a functional plasmid DNA construct that transcribes both siRNA and miRNA-like effectors each of which targets the identical type 1 translocation junction region of the EWS/FLI1 transcribed mRNA s...
שמור ב:
הוצא לאור ב: | Mol Ther |
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Main Authors: | , , , , , , , , |
פורמט: | Artigo |
שפה: | Inglês |
יצא לאור: |
Nature Publishing Group
2016
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נושאים: | |
גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5023384/ https://ncbi.nlm.nih.gov/pubmed/27166877 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2016.93 |
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