Phase 1 Trial of Bi-shRNA STMN1 BIV in Refractory Cancer

Stathmin1 (STMN1) is a microtubule modulator that is expressed in multiple cancers and correlates with poor survival. We previously demonstrated in vivo safety of bifunctional (bi) shRNA STMN1 bilamellar invaginated vesicle (BIV) and that systemic delivery correlated with antitumor activity. Patient...

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Foilsithe in:Mol Ther
Main Authors: Barve, Minal, Wang, Zhaohui, Kumar, Padmasini, Jay, Christopher M, Luo, Xiuquan, Bedell, Cynthia, Mennel, Robert G, Wallraven, Gladice, Brunicardi, Francis Charles, Senzer, Neil, Nemunaitis, John, Rao, Donald D
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group 2015
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Original Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4817753/
https://ncbi.nlm.nih.gov/pubmed/25619726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2015.14
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