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How motif environment influences transcription factor search dynamics: Finding a needle in a haystack

Transcription factors (TFs) have to find their binding sites, which are distributed throughout the genome. Facilitated diffusion is currently the most widely accepted model for this search process. Based on this model the TF alternates between one‐dimensional sliding along the DNA, and three‐dimensi...

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Detalhes bibliográficos
Publicado no:Bioessays
Main Authors: Dror, Iris, Rohs, Remo, Mandel‐Gutfreund, Yael
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5023137/
https://ncbi.nlm.nih.gov/pubmed/27192961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bies.201600005
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