Ablation of Glutaredoxin-1 Modulates House Dust Mite–Induced Allergic Airways Disease in Mice

Protein S-glutathionylation (PSSG) is an oxidant-induced post-translational modification of protein cysteines that impacts structure and function. The oxidoreductase glutaredoxin-1 (Glrx1) under physiological conditions catalyzes deglutathionylation and restores the protein thiol group. The involvem...

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Veröffentlicht in:Am J Respir Cell Mol Biol
Hauptverfasser: Hoffman, Sidra M., Qian, Xi, Nolin, James D., Chapman, David G., Chia, Shi Biao, Lahue, Karolyn G., Schneider, Robert, Ather, Jennifer L., Randall, Matthew J., McMillan, David H., Jones, Jane T., Taatjes, Douglas J., Aliyeva, Minara, Daphtary, Nirav, Abdalla, Sarah, Lundblad, Lennart K. A., Ho, Ye-Shih, Anathy, Vikas, Irvin, Charles G., Wouters, Emiel F. M., Reynaert, Niki L., Dixon, Anne E., van der Vliet, Albert, Poynter, Matthew E., Janssen-Heininger, Yvonne M. W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Thoracic Society 2016
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Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5023028/
https://ncbi.nlm.nih.gov/pubmed/27035878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2015-0401OC
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