Long-term treatment with metformin in obese, insulin-resistant adolescents: results of a randomized double-blinded placebo-controlled trial

BACKGROUND: As adolescents with obesity and insulin resistance may be refractory to lifestyle intervention therapy alone, additional off-label metformin therapy is often used. In this study, the long-term efficacy and safety of metformin versus placebo in adolescents with obesity and insulin resista...

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Detalhes bibliográficos
Publicado no:Nutr Diabetes
Main Authors: van der Aa, M P, Elst, M A J, van de Garde, E M W, van Mil, E G A H, Knibbe, C A J, van der Vorst, M M J
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5022149/
https://ncbi.nlm.nih.gov/pubmed/27571249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nutd.2016.37
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