Pharmacokinetic Modeling and Dose Selection in a Randomized, Double-Blind, Placebo-Controlled Trial of a Human Recombinant Alkaline Phosphatase in Healthy Volunteers

BACKGROUND AND OBJECTIVE: Previous clinical trials have suggested that bovine intestinal alkaline phosphatase has renal protective effects in patients with sepsis-associated acute kidney injury. We conducted a first-in-human study to investigate the pharmacokinetics, safety and tolerability of a nov...

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Pubblicato in:Clin Pharmacokinet
Autori principali: Peters, Esther, Heuberger, Jules A. A. C., Tiessen, Renger, van Elsas, Andrea, Masereeuw, Rosalinde, Arend, Jacques, Stevens, Jasper, Pickkers, Peter
Natura: Artigo
Lingua:Inglês
Pubblicazione: Springer International Publishing 2016
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Original Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5021756/
https://ncbi.nlm.nih.gov/pubmed/27147514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40262-016-0399-y
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