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Endothelial sirtuin 1 inactivation enhances capillary rarefaction and fibrosis following kidney injury through Notch activation

Peritubular capillary (PTC) rarefaction along with tissue fibrosis is a hallmark of chronic kidney disease (CKD). However, molecular mechanisms of PTC loss have been poorly understood. Previous studies have demonstrated that functional loss of endothelial sirtuin 1 (SIRT1) impairs angiogenesis durin...

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Bibliografiske detaljer
Udgivet i:Biochem Biophys Res Commun
Main Authors: Kida, Yujiro, Zullo, Joseph A., Goligorsky, Michael S.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5021614/
https://ncbi.nlm.nih.gov/pubmed/27524235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2016.08.066
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