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Phosphatidylserine Converts Immunogenic Recombinant Human Acid Alpha-Glucosidase to a Tolerogenic Form in a Mouse Model of Pompe Disease
Development of unwanted immune responses against therapeutic proteins is a major clinical complication. Recently, we have shown that exposure of Factor VIII (FVIII) in the presence of phosphatidylserine (PS) induces antigen-specific hypo-responsiveness to FVIII re-challenge, suggesting that PS is no...
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| Veröffentlicht in: | J Pharm Sci |
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| Hauptverfasser: | , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2016
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5021602/ https://ncbi.nlm.nih.gov/pubmed/27488899 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.xphs.2016.06.018 |
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