Osteopontin Promotes Expression of Matrix Metalloproteinase 13 through NF-κB Signaling in Osteoarthritis

Osteopontin (OPN) is associated with the severity and progression of osteoarthritis (OA); however, the mechanism of OPN in the pathogenesis of OA is unknown. In this study, we found that OA patients had higher abundance of OPN and matrix metalloproteinase 13 (MMP13). In chondrocytes, we showed that...

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Bibliographic Details
Published in:Biomed Res Int
Main Authors: Li, Yusheng, Jiang, Wei, Wang, Hua, Deng, Zhenhan, Zeng, Chao, Tu, Min, Li, Liangjun, Xiao, Wenfeng, Gao, Shuguang, Luo, Wei, Lei, Guanghua
Format: Artigo
Language:Inglês
Published: Hindawi Publishing Corporation 2016
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5021466/
https://ncbi.nlm.nih.gov/pubmed/27656654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2016/6345656
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