Osteopontin Promotes Expression of Matrix Metalloproteinase 13 through NF-κB Signaling in Osteoarthritis

Osteopontin (OPN) is associated with the severity and progression of osteoarthritis (OA); however, the mechanism of OPN in the pathogenesis of OA is unknown. In this study, we found that OA patients had higher abundance of OPN and matrix metalloproteinase 13 (MMP13). In chondrocytes, we showed that...

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Detalhes bibliográficos
Publicado no:Biomed Res Int
Main Authors: Li, Yusheng, Jiang, Wei, Wang, Hua, Deng, Zhenhan, Zeng, Chao, Tu, Min, Li, Liangjun, Xiao, Wenfeng, Gao, Shuguang, Luo, Wei, Lei, Guanghua
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5021466/
https://ncbi.nlm.nih.gov/pubmed/27656654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2016/6345656
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