Genome-Wide Assessment of Efficiency and Specificity in CRISPR/Cas9 Mediated Multiple Site Targeting in Arabidopsis

Simultaneous multiplex mutation of large gene families using Cas9 has the potential to revolutionize agriculture and plant sciences. The targeting of multiple genomic sites at once raises concerns about the efficiency and specificity in targeting. The model Arabidopsis thaliana is widely used in bas...

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Pubblicato in:PLoS One
Autori principali: Peterson, Brenda A., Haak, David C., Nishimura, Marc T., Teixeira, Paulo J. P. L., James, Sean R., Dangl, Jeffery L., Nimchuk, Zachary L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2016
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5021288/
https://ncbi.nlm.nih.gov/pubmed/27622539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0162169
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