Alpha-Synuclein Proteins Promote Pro-Inflammatory Cascades in Microglia: Stronger Effects of the A53T Mutant

Parkinson’s disease (PD) is histologically described by the deposition of α-synuclein, whose accumulation in Lewy bodies causes dopaminergic neuronal death. Although most of PD cases are sporadic, point mutations of the gene encoding the α-synuclein protein cause inherited forms of PD. There are cur...

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Publicat a:PLoS One
Autors principals: Hoenen, Claire, Gustin, Audrey, Birck, Cindy, Kirchmeyer, Mélanie, Beaume, Nicolas, Felten, Paul, Grandbarbe, Luc, Heuschling, Paul, Heurtaux, Tony
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2016
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5021287/
https://ncbi.nlm.nih.gov/pubmed/27622765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0162717
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